Berea Police arrested Jordan Palmer, 26, and Andrea Baker, 23, at Knights Inn in Berea on Thursday.
In addition, investigators said they found two burned spoons in the hotel room and believe the adults gave methamphetamine to the minor.
Palmer and Baker are both charged with unlawful transaction with a minor.
Palmer is also facing charges of rape, while Baker faces charges of sexual abuse.
Police said they are still investigating the case and more charges are pending.