Investigators said Johnny Lawson, 34, Stoney Fork, was last seen Friday afternoon at the Somerview Personal Care Home on North Main Street.
Police said Lawson had never returned home from a walk.
Investigators said he suffered from a medical condition.
Lawson was 6 feet tall and weighed 267 pounds.
He was last seen wearing a white t-shirt with black zip-up hoodie with blue jeans or blue jean shorts.
Anyone who had seen Lawson was asked to call 911.