It happened just before 8:30 on KY-770, about eleven miles outside of London.
Investigators said a driver lost control on the wet road.
Deputies said the car slid sideways and downhill before hitting a minivan traveling the other direction.
Investigators said the man driving the car, Eric Grubb, 32, London, was pronounced dead at the hospital.
Three people in the minivan reportedly suffered non-life threatening injuries.