According to officials, KY 78 will be closed at mile point 11.2, commonly known as the Pevyhouse Branch overpass.
Officials said there will be no signed detour and suggest that drivers take Spoonamore Lane to Blue Lick Road as a detour around the bridge replacement.
Officials also suggested that truck traffic should only use US 150 and US 127 through Hustonville and Danville.
Work is expected to last four weeks, transportation officials said. They did warn that the starting date and duration of construction may be changed for weather or other unforeseeable delays.
They said that drivers should expect delays and are encouraged to allow extra time in reaching their destination.