They said the house on East Highway 36 was engulfed in flames at around 1 am.
Officers said 69-year-old Susan Hicks was make it out of the burning home by herself, but her husband, 73-year-old Scottie Hicks, was still inside.
Fire crews were able to pull Hicks from the house.
He was flown to UK Hospital and listed in critical condition. He died the following day.
Mrs. Hicks was taken to a nearby hospital and treated for smoke inhalation.
No word yet on what caused the fire.