The coroner said James Quinn, 46, of Lexington and Rebecca Quinn, 43, of Lexington, both died of multiple blunt force trauma.
Rebecca Quinn was pronounced dead at the scene. James Quinn died a short time later at UK Hospital.
Lexington Police said a southbound pickup truck with a trailer crossed the center line on Nicholasville Road and collided with a car and an SUV.
The two people who died were in the SUV.
Investigators said two other people suffered non-life threatening injuries.
The road was partially closed all evening. It reopened around 11:00 p.m.
The Lexington Police Department’s Collision Reconstruction Unit (CRU) is investigating the deadly accident.
Meantime, Lexington Police said there was a second crash Friday night less than a mile away from the scene of the deadly afternoon accident.
Investigators said the second crash was a ‘chain reaction’ that involved three vehicles near Nicholasville Road and Brannon Crossing.
Police said one person was taken to the hospital.