Investigators said a car traveling south on U.S. 25, just south of London, crossed into the northbound lane and collided with a pickup truck head-on.
Investigators said the driver of the car had to be cut out of the vehicle and was airlifted to U.K. Hospital with serious injuries.
The driver of the pickup was taken to St. Joseph Hospital in London.
No names have been released.
The accident is still under investigation.