WebMD Medical News
Louise Chang, MD
Sept. 15, 2008 -- Widely prescribed, newer-generation antipsychotic drugs are no more effective for the treatment of schizophrenia in children and teens than older, cheaper drugs, a government-funded
Under the direction of the National Institute of Mental Health (NIMH),
researchers compared two of the newer drugs, known as atypical antipsychotics,
to an older-generation antipsychotic.
They found no major differences in treatment outcomes, but big differences
in side effects among young patients taking the newer and older drugs.
The findings are similar to a larger NIMH study in adults with
schizophrenia, published in 2005.
Children and teens who took the newer drugs Zyprexa and risperidone gained about 13 pounds and 8
pounds, respectively, during the two-month treatment part of the study.
The Zyprexa-treated patients also experienced increases in total cholesterol, LDL "bad" cholesterol, insulin, and
liver enzymes. Such metabolic side effects in addition to risk for obesity "generate considerable long-term risks
for diabetes and cardiovascular disease," the researchers noted.
The patients who took the older antipsychotic drug molindone (also known as
Moban) experienced no weight gain, but did have more akathisia (movement
disorder involving restlessness and need to fidget).
"All three of these drugs have different side effect profiles, but the
newer drugs are much more likely to cause weigh gain," says psychiatrist
and study researcher Linmarie Sikich, MD of the University of North
Sikich points out that almost all children and adolescents now treated for
schizophrenia start treatment on the newer, atypical drugs.
She adds that the American Academy of Child and Adolescent Psychiatry
(AACAP) -- the nation's leading pediatric mental health organization --
recommends the second-generation drugs as the first-line treatment for
schizophrenia in children and teens.
"At the very least, we think these results mean AACAP needs to revisit
these guidelines," she says.
Erin Baker, a spokeswoman for AACAP, tells WebMD that the group is doing
"We are currently revising our practice parameter for schizophrenia and
will take into account all data, including this new information," Baker
A spokesman for Zyprexa manufacturer Eli Lilly says the new study paints an
incomplete picture of the side effect profile of molindone and other
The second-generation drugs were developed in large part to avoid these side
effects, which can include tics, rigidity, and even an irreversible,
Parkinson's-like syndrome that can be crippling.
Jamaison Schuler of Eli Lilly tells WebMD that the eight-week treatment arm
of the study was far too short to assess the risk for the well established,
long-term side effects.
"Physicians balance such potentially disabling and irreversible movement
disorders associated with many first-generation antipsychotics with the
potential metabolic adverse events associated with the second-generation drugs
when considering what therapy is best for each patient," he says.
The patients in the study who took the first-generation drug also took
another drug used to reduce these movement-related side effects, which is a
common treatment practice.
The study included 116 children and teens aged 8-19 who had been diagnosed
with early-onset schizophrenia spectrum disorder (EOSS).
After eight weeks of treatment, 50% of the study participants taking
molindone showed improvement in schizophrenia symptoms, compared to 46% of patients
taking risperidone and 34% of patients on Zyprexa. There were no statistically
significant differences among the improvements seen in the three different
The study is published online in the latest issue of the American Journal
Although schizophrenia is not commonly found in children under 12, the
Department of Health & Human Services estimates it occurs in about three
out of every 1,000 adolescents.
NIMH chief of child psychiatry Judith Rapoport, MD, agrees that the study
was too small and the treatment arm too short to capture the full side effect
profile of the older-generation drugs.
But she adds that periodically taking patients off molindone and other older
antipsychotic treatments can help mitigate the risk for permanent side
"The pendulum has probably swung too far in the direction of the newer
generation of drugs," Rapoport tells WebMD. "There are probably
children who would be better off taking a low-dose of a first-generation drug
instead of a second-generation drug, especially if they gain a lot of weight on
these newer drugs."
NIMH director Thomas Insel, MD, tells WebMD that the new study and the
earlier trial in adults illustrate the need for better antipsychotic drugs.
At best, only half of the patients in the study responded to the medication
they were on. And just 10% to 20% of the patients continued treatment for a
"We really need a new era of drug development for psychotic illness,
both in children and adults," Insel says. "These studies remind us that
we are not where we want to be in the treatment of psychosis. There are just
too many people who aren't getting better."
Teva Pharmaceuticals, the maker of generic risperidone, was contacted but
WebMD did not receive comment by publication time.
SOURCES:Sikich, L. American Journal of Psychiatry, online edition, Sept. 15,
2008.Linmarie Sikich, MD, associate professor of psychiatry, University of North
Carolina at Chapel Hill.Thomas R. Insel, MD, director, National Institute of Mental Health,
Bethesda, Md.Judith Rapoport, MD, practicing child psychiatrist and chief of child
psychiatry branch, NIMH, Bethesda, Md.Erin Baker, spokeswoman, American Academy of Child and Adolescent
Psychiatry.Jamaison Schuler, spokesman, Eli Lilly and Company.http://www1.nmha.org/children/prevent/stats.cfm
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