In 10 Nationwide starts at Bristol, Bayne has scored three top-10 finishes, including a sixth-place run here last August.
"Bristol is one of my favorite tracks, and it's always good to get back in front of my hometown crowd," Bayne said. "It's one of the rare times I get to spend time with family and friends. We have been running consistently this year, and I know we will unload with a fast car for Saturday, so I'm looking forward to it."
Bayne is in his second full season as driver of the No. 6 Ford for Roush Fenway Racing in Nationwide. He has two career wins in the series, with his most recent victory occurring last June at Iowa.
In 2011, Bayne shocked the racing world by winning the Daytona 500, which happened one day after he turned 20 years old. He is running a partial schedule for Wood Brothers Racing in the Sprint Cup Series this season.
Last November, Bayne announced that he had been diagnosed with multiple sclerosis. He was cleared by doctors and NASCAR to race.
Of those drivers currently in the top-five in Nationwide points, Elliott Sadler is the only one who has won at Bristol. Sadler claimed the victory in the spring race here two years ago.
Kyle Busch, Kevin Harvick, Matt Kenseth and Kyle Larson are those Sprint Cup regulars scheduled to compete in Saturday's 300-lap race at Bristol. Busch scored a season-sweep at this track last year.
Ryan Blaney, a Camping World Truck Series regular, is driving the No. 22 Nationwide car for Team Penske at Bristol. Brad Keselowski drove that car to victory in last weekend's race at Las Vegas.
Forty-two teams are on the entry list for the Drive to Stop Diabetes 300.
Series: NASCAR Nationwide. Date: Saturday, March 15. Race: Drive to Stop Diabetes 300. Site: Bristol Motor Speedway. Track: 0.533-mile oval. Start time:2 p.m. ET. Laps: 300. Miles: 159.9. 2013 Winner: Kyle Busch. Television: ESPN2. Radio: Performance Racing Network (PRN)/SIRIUS NASCAR Radio.