The UK baseball team dug an early 3-0 hole with Kyle Cody on the mound before a lengthy weather delay.
But the Bat Cats fought back in the bottom of the first inning to tie things up. A three-run homer by Ka'ai Tom with an 0-2 count brought home A.J. Reed (walked) and Max Kuhn (singled).
Again, Kentucky trailed 6-3 until the bottom of the fourth when the Cats staged another 3-run inning to square things up at 6 before a lengthy weather delay.
When play resumed, Kansas took control and hung the loss on UK's Chandler Shepherd. 10-6 the final in the opening regional round game.
It's the fourth straight time the Bat Cats have dropped a regional opener.
Kentucky will now play in an elimination game on Saturday at 1 ET.
Highlights and full game coverage from Louisville coming up on ABC 36 News at 11.