A motorcycle headed east on Old Frankfort Pike was driving in the wrong lane when it hit an oncoming SUV, according to Versailles police.
They said the motorcyclist was ejected and landed in a tree.
The impact also caused the SUV to flip, landing on its top.
The motorcyclist was taken to a nearby hospital with serious but non life-threatening injuries and was wearing a helmet, according to officials.
The driver of the SUV was treated at the scene for minor injuries.