Police believe one truck cut the other one off and that triggered the dangerous showdown that ended at the Welcome Center.
KSP investigators say the Welcome Center is where the truckers decided to pull over to fight, after exchanging words back-and-forth on their CB radios.
"When they did stop, exited their vehicles, they both got out with sticks. One person struck the other person with a stick and the person that had been struck is the one we understand pulled the pistol and fired the rounds," says Sgt. Tom Atkin of Kentucky State Police's London Post.
KSP says one man was struck in the arm and was taken to the hospital with what appears to be non-life threatening injuries.
Police say at this time, charges aren't being filed against either man.